PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4114)
Related Products (4114)
-
PROTAC Linkers Isoform Comparison
-
N-(3-Hydroxypropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
0 ImagesCat. No.: HY-W117416CAS No.: 1449134-30-8
-
m-PEG9-CH2COOH
0 ImagesCat. No.: HY-133286CAS No.: 405518-55-0
-
2-(2-(Piperazin-1-yl)ethoxy)acetic acid
0 ImagesCat. No.: HY-W612530CAS No.: 197969-01-0
-
Ethyl [1,4'-bipiperidine]-4-carboxylate
![Ethyl [1,4'-bipiperidine]-4-carboxylate](https://file.medchemexpress.com/product_pic/hy-w236616.gif "Click to View Ethyl [1,4'-bipiperidine]-4-carboxylate Product Detail")
0 ImagesCat. No.: HY-W236616CAS No.: 344779-08-4
-
tert-Butyl ([1,4'-bipiperidin]-4-ylmethyl)carbamate
![tert-Butyl ([1,4'-bipiperidin]-4-ylmethyl)carbamate](https://file.medchemexpress.com/product_pic/hy-w791598.gif "Click to View tert-Butyl ([1,4'-bipiperidin]-4-ylmethyl)carbamate Product Detail")
0 ImagesCat. No.: HY-W791598CAS No.: 883512-84-3
-
m-PEG3-Hydrazide
0 ImagesCat. No.: HY-133344CAS No.: 1442104-10-0
-
Decanedioic acid ammonium
0 ImagesCat. No.: HY-W012158CAS No.: 19402-63-2Synonyms: Sebacic acid ammonium; Ammonium decanedioate; Diammonium sebacate
-
13-Methoxy-13-oxotridecanoic acid
0 ImagesCat. No.: HY-W989534CAS No.: 3927-59-1
-
Ethyl 2-(hydroxymethyl)cyclopropanecarboxylate
0 ImagesCat. No.: HY-W057671CAS No.: 15224-11-0
-
Alkyne-PEG4-I
0 ImagesCat. No.: HY-W692829CAS No.: 1383528-70-8
-
1-Boc-4-(4-Cyanobenzyl)piperazine
0 ImagesCat. No.: HY-W102045CAS No.: 849237-14-5
-
Benzyl (3-aminopropyl)(methyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W330302CAS No.: 1179362-94-7
-
Trt-PEG4-C2-COOH
0 ImagesCat. No.: HY-W096111CAS No.: 882847-05-4
-
tert-Butyl (azetidin-3-ylmethyl)carbamate oxalate
0 ImagesCat. No.: HY-W129529CAS No.: 1187929-81-2
-
Dibenzyl adipate
0 ImagesCat. No.: HY-W275450CAS No.: 2451-84-5
-
10-Bromo-1-aminodecane, Hydrobromide
0 ImagesCat. No.: HY-W739518CAS No.: 24566-82-3
-
Sulfonic chloride-C4-COOMe
0 ImagesCat. No.: HY-W613221CAS No.: 1408058-14-9
